Hydrochloric Acid → (4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%

HRID 579904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 579904
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH:13]NC(=O)C2C=CC=CC=2)=[S:12])[N:4]=1.[OH-].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH2:13])=[S:12])[N:4]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54321636HCID 54321636, Verbindung

Produkt 1

HCID 939981(4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%Ausbeute 102,5 %

Versuchsvorschrift

A mixture of 25 g of the compound from Example 3 and 55 ml of 10% aqueous sodium hydroxide was heated on the steam bath for 30 minutes, cooled, neutralized with aqueous HCl to pH 8, filtered, washed with water, dried by suction, and washed with ether to afford 16 g of the title compound, m.p. 220° d.

Aufarbeitung

  1. temperaturewas heated on the steam bath for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried by suction
  6. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-c13829d1f13f45e4bd71f23e498d6250
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04750930

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