Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 580114Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 580114
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

Produkt 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromideAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

Aufarbeitung

  1. temperatureThe reaction solution was cooled
  2. customthe hydrobromic acid layer was separated from the chloroform layer
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-e12a4395f1a244cb9caf87dd5864593f
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04751302

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