Isatoic Anhydride → 2-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide

HRID 580464Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 580464
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[N:13]1([CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH:17]=[CH:16][N:15]=[CH:14]1>C(O)C>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:22][CH2:21][CH2:20][CH2:19][CH2:18][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:4]

Komponenten

4

Edukt 2

HCID 8359Isatoic AnhydrideHCID 43794804-(1H-imidazol-1-yl)butan-1-amine

Produkt 1

HCID 139527342-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1.63 g of isatoic anhydride, 1.39 g of 1H-imidazole-1-butanamine and 25 ml of ethanol was stirred at room temperature for 22 hours. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate and cooled. The desired product was isolated by filtration, mp 91°14 93° C.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-a2664955ec9f4ae7943c5f76078d3435
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04753944

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