1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → 1,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

HRID 580538Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 580538
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[CH:17]([C:20]1[N:25]=[C:24]([O:26][C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH:23]=[C:22]([CH3:34])[N:21]=1)([CH3:19])[CH3:18]>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:31][C:30]2[CH:29]=[CH:28][C:27]([O:26][C:24]3[CH:23]=[C:22]([CH3:34])[N:21]=[C:20]([CH:17]([CH3:19])[CH3:18])[N:25]=3)=[CH:33][CH:32]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

Komponenten

4

Edukt 2

HCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 20133966HCID 20133966, Verbindung

Produkt 1

HCID 201339651,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

3.0 g (0.013 mole) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 3.2 g (0.013 mole) of 4-(2-isopropyl-6-methylpyrimidin-4-yloxy)aniline are suspended in 30 ml of toluene and heated for 18 hours at reflux temperature in an inert gas atmosphere (nitrogen). After cooling, the precipitate is isolated by filtration, washed with alcohol and dried.

Aufarbeitung

  1. temperatureheated for 18 hours
  2. temperatureat reflux temperature in an inert gas atmosphere (nitrogen)
  3. temperatureAfter cooling
  4. customthe precipitate is isolated by filtration
  5. washwashed with alcohol
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-974fd465a25540a196a510ec2c481ca6
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04753940

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