Hydrochloric Acid → HCID 13933100, Verbindung
Reaktionsgleichung
[C:1]([N:4]([CH:6]1[CH:10]([CH3:11])[CH2:9][N:8]([C:12]2[C:21]([F:22])=[C:20]3[C:15]([C:16](=[O:29])[C:17]([C:26]([OH:28])=[O:27])=[CH:18][N:19]3[CH:23]3[CH2:25][CH2:24]3)=[CH:14][C:13]=2[F:30])[CH2:7]1)C)(=O)C.[ClH:31]>>[ClH:31].[CH:23]1([N:19]2[C:20]3[C:15](=[CH:14][C:13]([F:30])=[C:12]([N:8]4[CH2:9][CH:10]([CH3:11])[CH:6]([NH:4][CH3:1])[CH2:7]4)[C:21]=3[F:22])[C:16](=[O:29])[C:17]([C:26]([OH:28])=[O:27])=[CH:18]2)[CH2:25][CH2:24]1Komponenten
3
Versuchsvorschrift
7-[3-(N-Acetyl-N-methylamino)-4-methyl-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.56 g) was dissolved in 20% aqueous hydrochloric acid solution (5 ml) and refluxed for 2 hours. Then the reacting mixture was concentrated under reduced pressure, to the resulting residue was added ethanol (10 ml) and crystallized with cooling. The resulting precipitate was collected by filtration and recrystallized from methanol to give the title compound as pale yellow powder, mp 242°-246° C.
Aufarbeitung
- temperaturerefluxed for 2 hours
- concentrationThen the reacting mixture was concentrated under reduced pressure, to the resulting residue
- additionwas added ethanol (10 ml)