Hydrochloric Acid → 10-(cis-3-Amino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride

HRID 580593

Reaktionsgleichung

Reaktionsgleichung von HRID 580593
C(OC([NH:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:16]([F:33])=[CH:17][C:18]3[C:28](=[O:29])[C:27]([C:30]([OH:32])=[O:31])=[CH:26][N:20]4[CH:21]([CH3:25])[CH2:22][O:23][C:24]=2[C:19]=34)[CH2:10]1)=O)(C)(C)C.[ClH:34]>C(O)C>[ClH:34].[NH2:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:16]([F:33])=[CH:17][C:18]3[C:28](=[O:29])[C:27]([C:30]([OH:32])=[O:31])=[CH:26][N:20]4[CH:21]([CH3:25])[CH2:22][O:23][C:24]=2[C:19]=34)[CH2:10]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 7041939710-(cis-3-t-Butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

Produkt 1

HCID 7041983210-(cis-3-Amino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 10-(cis-3-t-butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (0.55 g) in ethanol (8 ml) and ethanolic hydrochloride solution (10 ml) was stirred for 2 hours at room temperature and then concentrated. To the resulting residue was added ethanol and the resulting precipitate was collected by filtration and then washed with hot ethanol to give the title compound (0.5 g) as yellowish powder, mp 298° C. (decompd.)

Aufarbeitung

  1. concentrationconcentrated
  2. additionTo the resulting residue was added ethanol
  3. filtrationthe resulting precipitate was collected by filtration
  4. washwashed with hot ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f194e868aec84d8e86ff5e1b8948d87c
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04753953

Verknüpfte Notizen

Wird geladen…