2-Nitrophenol → HCID 2500489, Verbindung

HRID 581181Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 581181
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH3:17][N:18]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:19](=[O:22])[CH2:20]Br>CN(C)C=O>[CH3:17][N:18]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:19](=[O:22])[CH2:20][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 69472-NitrophenolHCID 11430Potassium CarbonateHCID 344952-Bromo-N-methyl-N-phenylacetamide

Produkt 1

HCID 2500489HCID 2500489, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
67.5 °C

Versuchsvorschrift

2-Nitrophenol S7 (2.8 g), anhydrous potassium carbonate (4.1 g), and N-methyl-N-phenyl-2-bromoacetamide (4.5 g) were suspended in N,N-dimethylformamide (50 ml), and the resulting suspension was stirred at 65-70° C. for 3 hours. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was washed with water and brine, then dried over anhydrous magnesium sulfate. The solvent was distilled off, obtaining 5.4 g of the compound S8.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-cb54b45bb82349408f29369222275e55
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05919824

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