Ammonia hydroxide → HCID 118024526, Verbindung

HRID 58172

Reaktionsgleichung

Reaktionsgleichung von HRID 58172
F[C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[OH-].[NH3:17]>CO>[CH3:14][N:13]([CH3:15])[CH2:12][CH2:11][C:4]1[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([NH2:17])[CH:3]=1

Komponenten

4

Edukt 2

HCID 21862953Ammonia hydroxideHCID 118024700[2-(3-Fluoro-4-nitro-phenyl)-ethyl]-dimethyl-amine

Produkt 1

HCID 118024526HCID 118024526, VerbindungAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of [2-(3-fluoro-4-nitro-phenyl)-ethyl]-dimethyl-amine (800 g, 3.76 mmol) in MeOH (20 mL) was added ammonia hydroxide (5 mL). The reaction mixture was heated at 100° C. under microwave heating for 1.5 hours. The resulting yellow solid was collected and washed with water, dried under vacuum and combined with a previous batch to give the pure title compound (560 mg, yield: 55%). MS (ESI): 210 [M+H]+.

Aufarbeitung

  1. temperatureheating for 1.5 hours
  2. customThe resulting yellow solid was collected
  3. washwashed with water
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0d6f805db90f42b1a9f8c164f28747a3
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434697B2

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