6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione → 1-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione

HRID 581877

Reaktionsgleichung

Reaktionsgleichung von HRID 581877
[CH2:1]([C:3]1[C:4](=[O:20])[NH:5][C:6](=[O:19])[NH:7][C:8]=1[C:9](=[O:18])[C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[Si]([O:28][CH2:29][CH:30]1[CH:34]([CH2:35][O:36][Si](C(C)(C)C)(C)C)[CH2:33][C:32]([CH2:44]Br)=[CH:31]1)(C(C)(C)C)(C)C>>[OH:28][CH2:29][CH:30]1[CH:34]([CH2:35][OH:36])[CH2:33][C:32]([CH2:44][N:7]2[C:8]([C:9](=[O:18])[C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:20])[NH:5][C:6]2=[O:19])=[CH:31]1

Komponenten

3

Edukt 2

HCID 222565796-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dioneHCID 54350482[3,4-Di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide

Produkt 1

HCID 699778101-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedioneAusbeute 25 %

Versuchsvorschrift

5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and [3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide were reacted by the same method with example 28 to obtain the titled compound (68 mg).

Quellen und Nachweise

ORD-Eintrag
ord-62d2525d6ff54071955c2f48e897da39
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05922727

Verknüpfte Notizen

Wird geladen…