HCID 53660198, Verbindung → 1H-Indole, 5-broMo-6-Methoxy-

HRID 581990Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 581990
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[N:7](S(C)(=O)=O)[CH:6]=[CH:5]2>[OH-].[Na+].C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][CH:6]=[CH:5]2

Komponenten

4

Edukt 1

HCID 53660198HCID 53660198, Verbindung

Produkt 1

HCID 534184371H-Indole, 5-broMo-6-Methoxy-Ausbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

The 1-methylsulphonylindole (D19, 21.2 g, 69.7 mmol) was heated under reflux in a mixture of 10% aqueous sodium hydroxide solution (170 ml) and ethanol (1.0 L) for 1.5 h. The mixture was evaporated almost to dryness, and the residue was dissolved in ethyl acetate and washed with water. The organic phase was dried and evaporated to give the title compound (15.65 g, 99%), mp 110-111° C.

Aufarbeitung

  1. customThe mixture was evaporated almost to dryness
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with water
  4. customThe organic phase was dried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-30c79622ed794261a725e7ef08475ba7
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05922733

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