HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isopropanol → (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzoimidazole-2-yl)(piperidin-4-yl)amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isopropanol | HCID 3776 | — |
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine | HCID 22009043 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzoimidazole-2-yl)(piperidin-4-yl)amine | HCID 22009201 | — |
Reaktionsschritte
Combine (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (1 mmol), potassium hydroxide (1.2 mmcl), and isopropanol (20 mL). Heat to reflux. After 18 hours, evaporate intcacuo to give a residue. Combine the resczue and water. Extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05922737 |
| Quelldatensatz | uspto-grants-1999_07 |
| ORD ID | ord-d21f8daaa0be4e20a557898196d14481 |
| Quellennotiz | uspto-grants-1999_07 |