Dichloromethane → Methyl 4-chloro-3-oxopentanoate
Reaktionsgleichung
[O:1]=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].C(Cl)[Cl:11]>>[Cl:11][CH:8]([CH3:9])[C:2](=[O:1])[CH2:3][C:4]([O:6][CH3:7])=[O:5]Komponenten
3
Versuchsvorschrift
To a solution of 3-oxopentanoic acid, methyl ester (Aldrich, 26.0 mL, 207.2 mmol) in methylene chloride (300 mL) was added in portions, N,N,N-trimethyl(phenyl) methanaminium dichloroiodanuide (75.71 g, 217.5 mmol). The reaction mixture was stirred at room temperature (rt) for 2 h, then washed with saturated sodium thiosulfate, brine, dried over magnesium sulfate and concentrated. The crude product was used directly in next step (23 g, 67.4%).
Aufarbeitung
- washwashed with saturated sodium thiosulfate, brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-1b9a8e6ed9864abbb2720e1815947720
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09434746B2
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