Sodium Hydroxide → 3-Oxo-2-[2-(pyrimidin-2-ylamino)ethyl]-2,3-dihydro-1H-isoindole-5-carboylic acid

HRID 582689Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 582689
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][N:9]([CH2:14][CH2:15][NH:16][C:17]1[N:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[C:8]2=[O:23])=[O:4].[OH-].[Na+]>CO>[O:23]=[C:8]1[C:7]2[C:11](=[CH:12][CH:13]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=2)[CH2:10][N:9]1[CH2:14][CH2:15][NH:16][C:17]1[N:18]=[CH:19][CH:20]=[CH:21][N:22]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 701040983-Oxo-2-[2-(pyrimidin-2-ylamino)ethyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid methyl ester

Produkt 1

HCID 701036023-Oxo-2-[2-(pyrimidin-2-ylamino)ethyl]-2,3-dihydro-1H-isoindole-5-carboylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A methanol solution (25 mL) of ester 6-3 (400 mg, 1.28 mmol) and 1 N NaOH (5 mL, 5 mmol) was stirred under ambient conditions for 18 hr. The reaction solution was concentrated to dryness and the residue was neutralized with 1 M NaHSO4 solution to provide 6-4 as a pale yellow solid.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-d8d9af5ab1ff43ef98267c260c2eedb7
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05925655

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