Methyl 5,6-Dichloronicotinate → Dimethyl 3-Chloro-2,6-pyridinedicarboxylate

HRID 582814

Reaktionsgleichung

Reaktionsgleichung von HRID 582814
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5](COC)=[CH:4][N:3]=1.ClC1C(Cl)=CC([C:20]([O:22][CH3:23])=[O:21])=CN=1>>[Cl:8][C:7]1[C:2]([C:20]([O:22][CH3:23])=[O:21])=[N:3][C:4]([C:20]([O:22][CH3:23])=[O:21])=[CH:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 2782166Methyl 5,6-DichloronicotinateHCID 111379602,3-Dichloro-5-(methoxymethyl)pyridine

Produkt 1

HCID 53845654Dimethyl 3-Chloro-2,6-pyridinedicarboxylateAusbeute 73 %

Versuchsvorschrift

Example 2 was repeated, except that the 2,3-dichloro-5-(methoxymethyl)pyridine was replaced by the same molar amount of methyl 2,3-dichloro-5-pyridinecarboxylate. After a reaction time of 6 hours at a bath temperature of 160° C., 1.20 g (73 percent) of a yellow product was obtained. Other data concerning the product was:

Quellen und Nachweise

ORD-Eintrag
ord-09075152a86f4f358289b2225de3bb1c
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05925765

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