Ethyl 3-(2-bromoethoxy)-2-methylbenzoate → Ethyl 3-(2-methylsulfonylthioethoxy)-2-methylbenzoate

HRID 582822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 582822
Br[CH2:2][CH2:3][O:4][C:5]1[C:6]([CH3:16])=[C:7]([CH:13]=[CH:14][CH:15]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9].[CH3:17][S:18]([O-:21])(=[S:20])=[O:19].[K+]>C(O)C>[CH3:17][S:18]([S:20][CH2:2][CH2:3][O:4][C:5]1[C:6]([CH3:16])=[C:7]([CH:13]=[CH:14][CH:15]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:21])=[O:19]

Komponenten

4

Edukt 2

HCID 15376195Ethyl 3-(2-bromoethoxy)-2-methylbenzoateHCID 23696406Potassium thiomethanesulfonate

Produkt 1

HCID 15376196Ethyl 3-(2-methylsulfonylthioethoxy)-2-methylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2 g (7 mmol) of ethyl 3-(2-bromoethoxy)-2-methylbenzoate and 1.1 g (7.3 mmol) of potassium thiomethanesulfonate are dissolved in 10 ml absolute ethanol. The reaction mixture is refluxed for 20 hours. The solvent is then distilled off and the residue taken up in methylene chloride and washed with water. The organic phase is dried over sodium sulfate and the solvent is removed. The product of value is purified by column chromatography.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 20 hours
  2. distillationThe solvent is then distilled off
  3. washwashed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is removed
  6. customThe product of value is purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-971a12ba684246ea9e0f633a678e70d6
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05925767

Notizen zur Reaktion

Wird geladen…