Pyridine → HCID 15220197, Verbindung

HRID 583049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 583049
N1C=CC=CC=1.[CH:7]1([C:10](Cl)=[O:11])[CH2:9][CH2:8]1.[NH2:13][C:14]1[CH:15]=[C:16]([C:21]2[C:25]([Cl:26])=[C:24]([O:27][CH:28]([F:30])[F:29])[N:23]([CH3:31])[N:22]=2)[CH:17]=[CH:18][C:19]=1[Cl:20]>O1CCCC1>[Cl:26][C:25]1[C:21]([C:16]2[CH:17]=[CH:18][C:19]([Cl:20])=[C:14]([NH:13][C:10]([CH:7]3[CH2:9][CH2:8]3)=[O:11])[CH:15]=2)=[N:22][N:23]([CH3:31])[C:24]=1[O:27][CH:28]([F:30])[F:29]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 77637Cyclopropanecarbonyl chlorideHCID 21226443HCID 21226443, Verbindung

Produkt 1

HCID 15220197HCID 15220197, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

1.0 g (13 mmol) of pyridine and 0.7 g (6.5 mmol) of cyclopropanecarbonyl chloride were added to a solution of 2.0 g (6.5 mmol) of 3-(3-amino-4-chlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole in 30 ml of tetrahydrofuran. The solution was stirred at room temperature overnight and at 50° C. for 2 hours, an then concentrated. The residue was taken up in ethyl acetate. The ethyl acetate was washed in succession with cold 1N hydrochloric acid, water and saturated sodium chloride solution, then dried over magnesium sulfate and finally concentrated. Yield: 2.2 g.

Aufarbeitung

  1. concentrationan then concentrated
  2. washThe ethyl acetate was washed in succession with cold 1N hydrochloric acid, water and saturated sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. concentrationfinally concentrated

Quellen und Nachweise

ORD-Eintrag
ord-0c3472d59bf94270b789077c1807dc69
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05928999

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