Sodium Hydroxide → 2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-3-trifluoromethyl-benzamide

HRID 583332Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 583332
[CH2:1]([N:8]([C:20]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:21]=1[C:30]#[N:31])[S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:32].[Na+]>C(O)CC>[CH2:1]([N:8]([S:9]([C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)(=[O:11])=[O:10])[C:20]1[C:25]([C:26]([F:29])([F:27])[F:28])=[CH:24][CH:23]=[CH:22][C:21]=1[C:30]([NH2:31])=[O:32])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 17866657N-Benzyl-N-(2-cyano-6-trifluoromethyl-phenyl)-4-methoxy-benzenesulfonamide

Produkt 1

HCID 213109172-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-3-trifluoromethyl-benzamideAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 10311-PropanolLösungsmittel

Versuchsvorschrift

To a solution of 1.78 g (4.0 mmol) of the product of Example 122 in 30 mL of n-propanol was added 8 mL of 5N NaOH solution. The resulting mixture was refluxed for 66 h and concentrated. The residue was stirred in water and filtered to provide 1.725 g (93%) of the desired amide as a white solid. Electrospray Mass Spec 465.2(M+H).

Aufarbeitung

  1. temperatureThe resulting mixture was refluxed for 66 h
  2. concentrationconcentrated
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-276fea84c4bd458293566e0614e945c2
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05929097

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