4-Fluorobenzenesulfonyl chloride → 3-Methyl-5-bromo-2-(4-fluoro-benzenesulfonylamino)-benzoic acid
Reaktionsgleichung
C[O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([CH3:11])[C:5]=1[NH2:12].[F:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[Br:10][C:8]1[CH:7]=[C:6]([CH3:11])[C:5]([NH:12][S:21]([C:18]2[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=2)(=[O:23])=[O:22])=[C:4]([CH:9]=1)[C:3]([OH:2])=[O:13]Komponenten
3
Versuchsvorschrift
By following the procedure of Example 134 the product of Example 133 and 4-flurobenzenesulfonyl chloride provides 5-bromo-2-(4-fluoro-benzenesulfonylamino)-3methyl-benzoic acid as a yellow solid in 36% yield. Electrospray Mass Spec: 386.0 (M-H)-
Quellen und Nachweise
- ORD-Eintrag
- ord-4549ad39d2c94529ac0f5329a4ac072c
- Quelldatensatz
- uspto-grants-1999_07