HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dichloromethane → (2-{2-[(Carboxy-phenyl-methyl)-carbamoyl]phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dichloromethane | HCID 6344 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | (2-{2-[(tert-Butoxycarbonyl-phenyl-methyl)carbamoyl]-phenyldisulfanyl}-benzoylamino)phenyl-acetic acid tert-butyl ester | HCID 76120819 | — |
| Lösungsmittel | Diethylether hexane | HCID 21584099 | — |
| Produkt | (2-{2-[(Carboxy-phenyl-methyl)-carbamoyl]phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid | HCID 465365 | 42,5% |
Reaktionsschritte
This compound was prepared according to the procedure described in Example 50 using [R-(R*,R*)] (2-{2-[(tert-butoxycarbonyl-phenyl-methyl)-carbamoyl]-phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid tert-butyl ester (0.2 g, 0.3 mmol) from Example 38, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The crude product was stirred with ether/hexane and filtered to afford 73.0 mg of the title compound, mp 231-232° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05929114 |
| Quelldatensatz | uspto-grants-1999_07 |
| ORD ID | ord-c3f6f8d91f60470cb601394de1578b01 |
| Quellennotiz | uspto-grants-1999_07 |