Hydrochloric Acid → 4-(2-Aminoethyloxy)benzoyl-2(S)-phenylsulfonylamino-beta-alanine-HCl

HRID 583666

Reaktionsgleichung

Reaktionsgleichung von HRID 583666
C([O:5][C:6](=[O:39])[C@@H:7]([NH:29][S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31])[CH2:8][NH:9][C:10](=[O:28])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][NH:20]C(OC(C)(C)C)=O)=[CH:13][CH:12]=1)(C)(C)C.O1CCOCC1.[ClH:46]>>[ClH:46].[NH2:20][CH2:19][CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:29][S:30]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)(=[O:32])=[O:31])[C:6]([OH:39])=[O:5])=[O:28])=[CH:12][CH:13]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 108406644-[2-(N-BOC-Amino)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butyl ester

Produkt 1

HCID 867543354-(2-Aminoethyloxy)benzoyl-2(S)-phenylsulfonylamino-beta-alanine-HCl

Versuchsvorschrift

A suspension of 2-3 (105 mg, 0.19 mmol) in 6N HCl (5 mL) was treated with dioxane (5 mL) to effect a homogeneous solution. After stirring for 20 h at ambient temperature, the solvents were evaporated and the resulting residue azeotroped with toluene to afford 12-1 as a colorless solid.

Aufarbeitung

  1. customthe solvents were evaporated
  2. customthe resulting residue azeotroped with toluene

Quellen und Nachweise

ORD-Eintrag
ord-3545c1a839b84107a6729d4bc39d022f
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05929120

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