HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 3,4,5-Trimethoxyphenyl 6-methoxy-3-pyridinesulfonate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 3,4,5-Trimethoxyphenol | HCID 69505 | — |
| Edukt | 6-Methoxypyridine-3-sulfonyl chloride | HCID 22344709 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 3,4,5-Trimethoxyphenyl 6-methoxy-3-pyridinesulfonate | HCID 10286875 | 83,3% |
Reaktionsschritte
A solution of 2-methoxypyridine-5-sulfonylchloride (314 mg, 1.51 mmol) in dichloromethane (15 mL) was treated with triethylamine (0.63 mL) and 3,4,5-trimethoxyphenol (279 mg, 1.51 mmol), stirred for 18 hours at room temperature, diluted with ethyl acetate, washed three times with 1M Na2CO3, dried (MgSO4), filtered, and concentrated to provide 447 mg of the desired product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06924304B2 |
| Quelldatensatz | uspto-grants-2005_08 |
| ORD ID | ord-e5cf63a01e114696b9636a9a1471802b |
| Quellennotiz | uspto-grants-2005_08 |