Hydrochloric Acid → 1-(4-Bromo-3-methylphenyl)propan-1-one

Reaktionsgleichung

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#N)=[CH:4][C:3]=1[CH3:10].[CH2:11]([Mg]Br)[CH3:12].Cl.[O:16]1CCOCC1>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[O:16])[CH2:11][CH3:12])=[CH:4][C:3]=1[CH3:10]

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 27374944-Bromo-3-methylbenzonitrile

HCID 178418443HCID 178418443, Verbindung

Produkt 1

HCID 223456201-(4-Bromo-3-methylphenyl)propan-1-one

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

24.7 g (126 mmol) of 4-bromo-3-methylbenzonitrile are dissolved in 400 ml of anhydrous dioxane and the medium is then cooled to 0° C. 124 ml (372 mmol) of ethylmagnesium bromide are added dropwise and the medium is then warmed to room temperature and stirred for 4 hours. The reaction medium is treated with 250 ml of 3N HCl and then extracted with a water/ether mixture. A white solid is obtained after trituration from heptane (m=14.5 g, Y=52%).