Methanesulfinic acid → HCID 9862981, Verbindung

HRID 584663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 584663
Cl[C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10][C:9]2[C:4](=[CH:5][C:6]([Cl:17])=[C:7]([Cl:16])[CH:8]=2)[N:3]=1.[CH3:18][S:19]([OH:21])=[O:20].[Na]>CN(C=O)C>[Cl:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[Cl:17])[N:3]=[C:2]([S:19]([CH3:18])(=[O:21])=[O:20])[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10]2

Komponenten

5

Edukt 3

HCID 87251Methanesulfinic acidHCID 5360545SodiumHCID 223410732,6,7-Trichloro-3-(trifluoromethyl)quinoxaline

Produkt 1

HCID 9862981HCID 9862981, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 2,6,7-trichloro-3-trifluoromethylquinoxaline (64 mg, 0.2 mmol) in DMF (1 ml) was added methanesulfinic acid, sodium salt (43 mg, 0.4 mmol). The reaction mixture was stirred at room temperature overnight, then it was partitioned between ethyl acetate and water. The organic layer was separated and concentrated to an oil. This oil was further purified by column chromatography (ethyl acetate:hexanes 1:3) to yield the title compound as a white solid.

Aufarbeitung

  1. customit was partitioned between ethyl acetate and water
  2. customThe organic layer was separated
  3. concentrationconcentrated to an oil
  4. customThis oil was further purified by column chromatography (ethyl acetate:hexanes 1:3)

Quellen und Nachweise

ORD-Eintrag
ord-0550dabd66cb443ab3c91089aeceef56
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06927214B1

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