Phosphorus tribromide → 2-Bromo-6,7-dichloro-3-trifluoromethylquinoxaline

HRID 584667Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 584667
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[NH:8][C:7](=O)[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5]2.P(Br)(Br)[Br:19]>>[Br:19][C:7]1[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5][C:4]2[C:9](=[CH:10][C:11]([Cl:12])=[C:2]([Cl:1])[CH:3]=2)[N:8]=1

Komponenten

3

Edukt 2

HCID 24614Phosphorus tribromideHCID 27678326,7-Dichloro-3-(trifluoromethyl)quinoxalin-2(1H)-one

Produkt 1

HCID 223411132-Bromo-6,7-dichloro-3-trifluoromethylquinoxaline

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

6,7-Dichloro-3-trifluoromethyl-1H-quinoxalin-2-one (500 mg, 1.8 mmol) was dissolved in phosphorus tribromide (2.0 ml), and the solution was heated at 140° C. for 16 hours. The reaction mixture was cooled to room temperature, before it was poured out on ice (100 g) and extracted with dichloromethane. The organic phase was separated and dried with anhydrous sodium sulphate, then taken to dryness by rotary evaporation to leave a pale brown powder.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temperature, before it
  2. additionwas poured out on ice (100 g)
  3. extractionextracted with dichloromethane
  4. customThe organic phase was separated
  5. dry with materialdried with anhydrous sodium sulphate
  6. customtaken to dryness by rotary evaporation
  7. customto leave a pale brown powder

Quellen und Nachweise

ORD-Eintrag
ord-dc8899de52194adc91c5541aac4ae9ef
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06927214B1

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