tert-Butyl 3-bromobenzyl(methyl)carbamate → HCID 91244259, Verbindung

HRID 585005

Reaktionsgleichung

Reaktionsgleichung von HRID 585005
Br[C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][N:6]([CH3:14])[C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10].[CH3:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][C:24]=1[CH:25]=[O:26]>>[CH:25]([C:24]1[CH:23]=[CH:22][C:21]([C:2]2[CH:17]=[CH:16][CH:15]=[C:4]([CH2:5][N:6]([CH3:14])[C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])[CH:3]=2)=[CH:20][C:19]=1[CH3:18])=[O:26]

Komponenten

3

Edukt 2

HCID 20738487tert-Butyl 3-bromobenzyl(methyl)carbamateHCID 22341466(4-Formyl-3-methylphenyl)boronic acid

Produkt 1

HCID 91244259HCID 91244259, VerbindungAusbeute 87 %

Versuchsvorschrift

In a manner similar to that of Example 1(e), by reacting 1.1 g (3.5 mmol) of tert-butyl (3-bromo-benzyl)-N-methylcarbamate obtained in Example 79(b) with 750 mg (4.6 mmol) of 3-methyl-4-formylbenzene-boronic acid, and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (7/3), 1 g (87%) of the expected product is obtained in the form of a yellow oil.

Aufarbeitung

  1. customafter purification by chromatography on a column of silica
  2. washeluted with a heptane/ethyl acetate mixture (7/3)

Quellen und Nachweise

ORD-Eintrag
ord-e164c78e9d0440669c5fe363ea31a06c
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06927228B2

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