Hydrochloric Acid → HCID 22340319, Verbindung

HRID 585304Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 585304
[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:14]C(=O)C)[CH:10]=2)[N:5]=1.Cl>>[ClH:2].[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:14])[CH:10]=2)[N:5]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 22340304HCID 22340304, Verbindung

Produkt 1

HCID 22340319HCID 22340319, VerbindungAusbeute 192,6 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To the N-[2-(chloromethyl)-6-quinolinyl]acetamide hydrochloride (900 mg, 3.32 mmol) obtained in Reference Example 6 was added 5N hydrochloric acid (17 ml), and the mixture was stirred at 100° C. for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was washed with tetrahydrofuran to obtain the titled compound (849 mg) as powders.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe resulting residue was washed with tetrahydrofuran

Quellen und Nachweise

ORD-Eintrag
ord-7e9601225fc44cf2886c0c71f3a0d6c6
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06930185B2

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