N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide → 2-(1-Pyrrolidinylmethyl)-6-quinolinylamine

HRID 585305Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 585305
[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH:17]C(=O)C)[CH:13]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 22340322N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide

Produkt 1

HCID 119945322-(1-Pyrrolidinylmethyl)-6-quinolinylamineAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To the N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide (5.53 g, 20.5 mmol) obtained in 1) of Example 7 was added concentrated hydrochloric acid (100 ml), the mixture was stirred at 110° C. for 1 hour, and the solvent was distilled off under reduced pressure. To the resulting residue was added ethyl acetate, the mixture was washed with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain the titled compound (4.56 g) as a powder from ethyl acetate-hexane.

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionTo the resulting residue was added ethyl acetate
  3. washthe mixture was washed with an aqueous potassium carbonate solution
  4. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e9e2182d72664dcc9b3a40e108dcb3f6
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06930185B2

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