3,4,5-Trimethoxybenzoic Acid → 1-(3,4,5-Trimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol

HRID 585365

Reaktionsgleichung

Reaktionsgleichung von HRID 585365
[CH3:1][CH:2]1[CH2:11][CH:10]([OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25])[C:18](O)=[O:19]>>[CH3:27][O:26][C:22]1[CH:21]=[C:17]([CH:16]=[C:15]([O:14][CH3:13])[C:23]=1[O:24][CH3:25])[C:18]([N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]([OH:12])[CH2:11][CH:2]1[CH3:1])=[O:19]

Komponenten

3

Edukt 2

HCID 83573,4,5-Trimethoxybenzoic AcidHCID 1476341,2,3,4-Tetrahydro-2-methyl-4-quinolinol

Produkt 1

HCID 223392301-(3,4,5-Trimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinolAusbeute 33,4 %

Versuchsvorschrift

Starting with 2-methyl-1,2,3,4-tetrahydro-4-quinolinol (3.00 g, 18.3 mmol) synthesized in the published manner and 3,4,5-trimethoxybenzoic acid (2.0 g, 10.9 mmol), the same procedure as shown in Reference Example 19 was repeated to give the titled compound (1.30 g, yield: 33%) as a white crystal. (cis:trans=1:1)

Quellen und Nachweise

ORD-Eintrag
ord-91dad63fa1104a4b976fec8693f72513
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06930104B2

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