2-Chloro-1-methylpyridinium iodide → (S)-4-(tert-butoxycarbonylamino)-N-(1-triphenylmethylpyrazolo[3,4-b]pyridin-4-yl)thiochromane-7-carboxamide

HRID 585742Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 585742
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[C:18]2[C:13](=[CH:14][C:15]([C:19](O)=[O:20])=[CH:16][CH:17]=2)[S:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:22][C:23]1[CH:28]=[CH:27][N:26]=[C:25]2[N:29]([C:32]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:30]=[CH:31][C:24]=12.[I-].ClC1C=CC=C[N+]=1C>>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([NH:22][C:23]3[CH:28]=[CH:27][N:26]=[C:25]4[N:29]([C:32]([C:33]5[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=5)([C:39]5[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=5)[C:45]5[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=5)[N:30]=[CH:31][C:24]=34)=[O:20])=[CH:16][CH:17]=2)[S:12][CH2:11][CH2:10]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Komponenten

4

Edukt 3

HCID 1670692-Chloro-1-methylpyridinium iodideHCID 223374704-Amino-1-triphenylmethylpyrazolo[3,4-b]pyridineHCID 59089455(S)-4-(tert-butoxycarbonylamino)thiochromane-7-carboxylic acid

Produkt 1

HCID 69619621(S)-4-(tert-butoxycarbonylamino)-N-(1-triphenylmethylpyrazolo[3,4-b]pyridin-4-yl)thiochromane-7-carboxamideAusbeute 73,8 %

Versuchsvorschrift

By a similar reaction operation as in Starting Material Synthetic Example 53 using (S)-4-(tert-butoxycarbonylamino)thiochromane-7-carboxylic acid (500 mg), 4-amino-1-triphenylmethylpyrazolo[3,4-b]pyridine (670 mg) synthesized according to a known method and 2-chloro-1-methylpyridinium iodide (496 mg), the objective (S)-4-(tert-butoxycarbonylamino)-N-(1-triphenylmethylpyrazolo[3,4-b]pyridin-4-yl)thiochromane-7-carboxamide (796 mg) was obtained as a pale yellow amorphous solid.

Aufarbeitung

  1. customsynthesized

Quellen und Nachweise

ORD-Eintrag
ord-96f348abe2ff423fb07d416f935fc79e
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933305B2

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