HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 2-Oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Edukt | 4-(Trifluoromethoxy)aniline | HCID 600848 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 2-Oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid | HCID 24689361 | 82,3% |
Reaktionsschritte
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and 4-(trifluoromethoxy)aniline (0.595 mL; 4.41 mmol) in ethanol (3 mL). 2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid 0.350 g (82%) was obtained as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434722B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-56b333c44e0549008827d4b10428caf3 |
| Quellennotiz | uspto-grants-2016_09 |