Sodium Hydroxide → Pantoprazole sodium (USP)

HRID 585775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 585775
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-:27].[Na+:28].C([O:33]C)(C)(C)C>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S:12]([C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)=[O:26])[C:8]=1[O:9][CH3:10].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S:12]([C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)=[O:26])[C:8]=1[O:9][CH3:10].[OH2:33].[OH2:27].[OH2:2].[Na+:28].[Na+:28]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 15413tert-Butyl methyl etherHCID 178493214Pantoprazole

Produkt 1

HCID 11954257Pantoprazole sodium (USP)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

Pantoprazole freebase (25 grams) was dissolved in a solution of ethyl acetate (50 ml) and aqueous sodium hydroxide solution (2.7 grams in 5 ml of water) and stirred at a temperature of 40-50° C. till the clear solution results. Methyl tertiary butyl ether (250 ml) was added to the reaction mixture and stirred for about 3-4 hours to crystallize the solid mass. The separated solid mass was filtered, washed with methyl tertiary butyl ether (50 ml) and suck dried under vacuum. The wet solid was further dried at a temperature of 40-50° C. to afford crystalline Form-I of Pantoprazole sodium sesquihydrate.

Aufarbeitung

  1. customresults
  2. stirringstirred for about 3-4 hours
  3. customto crystallize the solid mass
  4. filtrationThe separated solid mass was filtered
  5. washwashed with methyl tertiary butyl ether (50 ml)
  6. customsuck dried under vacuum
  7. customThe wet solid was further dried at a temperature of 40-50° C.

Quellen und Nachweise

ORD-Eintrag
ord-43bdbdff25ab423cacdd26ba42ac6d59
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933389B2

Notizen zur Reaktion

Wird geladen…