Trifluoroacetic acid → 4-(Aminomethyl)benzonitrile

HRID 585992Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 585992
C(OC([N:8]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=1)C(OC(C)(C)C)=O)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:24][CH2:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]#[N:8])=[CH:18][CH:19]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 3683768Tert-butyl N-[(4-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Produkt 1

HCID 826084-(Aminomethyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of N,N-bis(tert-butoxycarbonyl)-4-cyanobenzylamine (0.75 g, 2.25 mmol, prepared according to the literature described in Synthetic Communications 4419:28 (1998), in CH2Cl2 (15 mL) was treated with trifluoroacetic acid (8 mL). After stirring at room temperature for 3 hours, the mixuture was concentrated under reduced pressure and the residue was azeotroped with diethyl ether.

Aufarbeitung

  1. concentrationthe mixuture was concentrated under reduced pressure
  2. customthe residue was azeotroped with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-dd60b80001d84cedb391f105cd33e5a6
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933311B2

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