Phosgene → 3-Chloro-5-isocyanatoisoquinoline

HRID 585996

Reaktionsgleichung

Reaktionsgleichung von HRID 585996
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([Cl:12])[N:6]=[CH:7]2.[C:13](Cl)(Cl)=[O:14]>C1(C)C=CC=CC=1.C(N(CC)CC)C>[Cl:12][C:5]1[N:6]=[CH:7][C:8]2[C:3]([CH:4]=1)=[C:2]([N:1]=[C:13]=[O:14])[CH:11]=[CH:10][CH:9]=2

Komponenten

5

Edukt 2

HCID 6371PhosgeneHCID 167490403-Chloroisoquinolin-5-amine

Produkt 1

HCID 223376853-Chloro-5-isocyanatoisoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittel2×HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.

Aufarbeitung

  1. temperatureThe mixture was refluxed overnight
  2. concentrationwas then concentrated in vacuo
  3. customused in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-757cd4c7dec242c181a7146cfc9b9d54
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933311B2

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