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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 586073Erstellt: 26. Oktober 2026

1-Methyl-4-nitro-1H-indazole → 1H-Indazol-4-amine, 1-methyl-

https://huagongshe.com/reaction/586073

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt1-Methyl-4-nitro-1H-indazoleHCID 280213—
EduktHCID 178418361HCID 178418361—
KatalysatorHCID 178418390HCID 178418390—
LösungsmittelEthanolHCID 702—
Produkt1H-Indazol-4-amine, 1-methyl-HCID 153838—

Reaktionsschritte

1-Methyl-4-nitro-1H-indazole (6.1 g; 35.4 mmol) and 10% Pd/carbon (500 mg) were combined in ethanol and hydrogenated in a Parr apparatus at 60 PSI hydrogen at 50° C. for 1 hour. The mixture was allowed to cool to ambient temperature, filtered through Celite, and concentrated under reduced pressure to provide the title compound. 1H NMR (DMSO-d6) δ 8.02 (s, 1H), 7.02 (t, 1H), 6.62 (d, 1H), 6.14 (d, 1H), 5.75 (s, 2H), 3.90 (s, 2H).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06933311B2
Quelldatensatzuspto-grants-2005_08
ORD IDord-487ba7571ac24c22a48de22de3da1e24
Quellennotizuspto-grants-2005_08