Triethylamine → N-[4-({[2-(4-Bromophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]amino}-methyl)phenyl]acetamide

HRID 586157

Reaktionsgleichung

Reaktionsgleichung von HRID 586157
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([N:14]3C=NC=N3)[C:11]3=[C:19]([CH3:23])[N:20]=[C:21]([CH3:22])[N:10]3[N:9]=2)=[CH:4][CH:3]=1.[C:24]([NH:27][C:28]1[CH:35]=[CH:34][C:31]([CH2:32]N)=[CH:30][CH:29]=1)(=[O:26])[CH3:25].C(N(CC)CC)C>O1CCOCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[C:12]([NH:14][CH2:32][C:31]3[CH:30]=[CH:29][C:28]([NH:27][C:24](=[O:26])[CH3:25])=[CH:35][CH:34]=3)[C:11]3=[C:19]([CH3:23])[N:20]=[C:21]([CH3:22])[N:10]3[N:9]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 15295869N-[4-(aminomethyl)phenyl]acetamideHCID 223296222-(4-Bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine

Produkt 1

HCID 22329639N-[4-({[2-(4-Bromophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]amino}-methyl)phenyl]acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

2-(4-Bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]-triazine (3.7 mg, 10 mmol) is treated in dioxane (100 μl) with 4-acetylamino-benzylamine (3.3 mg, 20 mmol) and triethylamine (4 μl). The mixture is heated at 80° C. with shaking for 12 h, filtered and washed with DMSO (2×100 μl). The combined filtrates are purified chromatographically by preparative LC-MS.

Aufarbeitung

  1. filtrationfiltered
  2. washwashed with DMSO (2×100 μl)
  3. customThe combined filtrates are purified chromatographically by preparative LC-MS

Quellen und Nachweise

ORD-Eintrag
ord-220a3115004a4a9fa2dfcefbfc7be50a
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06936609B2

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