HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 586640Erstellt: 25. Oktober 2026
Chloroacetaldehyde → 7-phenyl-2,3-dihydro-1H-pyrrolizine
https://huagongshe.com/reaction/586640
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Chloroacetaldehyde | HCID 33 | — |
| Edukt | 5-benzyl-3,4-dihydro-2H-pyrrole | HCID 224018 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 7-phenyl-2,3-dihydro-1H-pyrrolizine | HCID 22335597 | — |
Reaktionsschritte
2-Benzyl-1-pyrroline (Example 1b, 85%, 74 g, 0.395 mol), dissolved in MeOH (360 ml), is treated with NaHCO3 (38 g, 0.45 mol), and the mixture is cooled to 5° C. A solution of chloroacetaldehyde (45% strength in water, 68 g, 0.4 mol), dissolved in MeOH (100 ml) is added dropwise to the solution at this temperature, and the mixture is stirred for 18 h with exclusion of light.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US06936632B2 |
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| Quelldatensatz | uspto-grants-2005_08 |
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| ORD ID | ord-2c184a92199544a6b599d95f66902770 |
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| Quellennotiz | uspto-grants-2005_08 |
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