Mycophenolic acid glucuronide → 2,6-Bisformyl bicyclo[2.2.1]heptane

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Next, the inside of the autoclave was sufficiently substituted by nitrogen, and then sufficiently substituted by a gas mixture having a volume ratio of carbon monoxide to hydrogen of 50/50. The same gas was injected until a pressure in the autoclave reached 0.6 MPaG, and the adjustment liquid was heated to 100° C. under stirring, thereby initiating a hydroformylation reaction. Since the pressure in the autoclave decreased with proceeds of the reaction, the gas mixture was continuously supplied so that the pressure was maintained at 0.6 MPaG, the temperature was adjusted so as to be maintained at 100° C., and the hydroformylation reaction was carried out for 6 hours. After the completion of the reaction, the gas mixture in the system was purged using nitrogen, and 280.1 g of a reaction liquid including 2,5-bisformyl bicyclo[2.2.1]heptane and 2,6-bisformyl bicyclo[2.2.1]heptane was obtained. An analysis showed that the reaction liquid contained 266.1 g (1.76 mol) of the compounds.

Herkunft & Nachweise