5-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester → 5-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid

HRID 588465Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 588465
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:30])[C:10]=1[C:11](=[O:29])[NH:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([N:19]=[C:20]([N:22]3[CH2:26][CH2:25][CH:24]([O:27][CH3:28])[CH2:23]3)[N:21]=2)[CH:18]=1)=[O:5])C.CN1C(C(=O)NC2C=CC3N(N=C(N4CCOCC4)N=3)C=2)=C(C(O)=O)C=N1>>[CH3:28][O:27][CH:24]1[CH2:25][CH2:26][N:22]([C:20]2[N:21]=[C:16]3[CH:15]=[CH:14][C:13]([NH:12][C:11]([C:10]4[N:9]([CH3:30])[N:8]=[CH:7][C:6]=4[C:4]([OH:5])=[O:3])=[O:29])=[CH:18][N:17]3[N:19]=2)[CH2:23]1

Komponenten

3

Edukt 2

HCID 894642715-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl esterHCID 894643091-Methyl-5-(2-morpholino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Produkt 1

HCID 894643825-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid

Versuchsvorschrift

Using 5-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester, this compound was prepared following the same method as for the synthesis of 1-Methyl-5-(2-morpholino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid. Off white solid (690 mg, 82%). MS: m/z=386 (M+H+).

Aufarbeitung

  1. customthis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-94088adcd3d14dd9828b6aabf5128207
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09227970B2

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