Hydrochloric Acid → 5-(1-Aminoethyl)thiophene-2-carboxylate hydrochloride

HRID 588502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 588502
C(OC([NH:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18]C)=[O:17])=[CH:14]N=1)[CH3:10])=O)(C)(C)C.[ClH:20].[CH3:21]O>O1CCOCC1>[ClH:20].[NH2:8][CH:9]([C:11]1[S:12][C:13]([C:16]([OH:18])=[O:17])=[CH:14][CH:21]=1)[CH3:10]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 67397774Methyl 2-(1-((tert-butoxycarbonyl)amino)ethyl)thiazole-5-carboxylate

Produkt 1

HCID 673953435-(1-Aminoethyl)thiophene-2-carboxylate hydrochlorideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.9 g, 3 mmol) in MeOH (5 mL) was added 4M HCl in dioxane (4 mL). The reaction was stirred overnight at room temperature. The reaction was evaporated to dryness to afford 5-(1-aminoethyl)thiophene-2-carboxylate hydrochloride (0.7 g, 100%).

Aufarbeitung

  1. customThe reaction was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c3649d2de7fc4711a31f99196f4546e7
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09227951B2

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