1-(5-Bromopyrimidin-2-yl)ethan-1-one → 2-(5-Bromopyrimidin-2-yl)propan-2-ol

HRID 589170

Reaktionsgleichung

Reaktionsgleichung von HRID 589170
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8](=[O:10])[CH3:9])=[N:6][CH:7]=1.[CH3:11][Mg]Br>C1COCC1>[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]([OH:10])([CH3:11])[CH3:9])=[N:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 534880641-(5-Bromopyrimidin-2-yl)ethan-1-oneHCID 178418573HCID 178418573, Verbindung

Produkt 1

HCID 584852862-(5-Bromopyrimidin-2-yl)propan-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of 1-(5-bromopyrimidin-2-yl)ethanone (100 mg, 0.5 mmol) in THF (10 mL) at −78° C. was added methylmagnesium bromide (1.4M solution, 3.6 mL, 5 mmol). The reaction mixture was stirred for an additional 20 minutes until LC/MS analysis indicated that the reaction was complete. Quenching with saturated NH4Cl, extraction with EtOAc and drying over MgSO4, afforded the crude residue which was taken forward as is in the next step.

Aufarbeitung

  1. customQuenching with saturated NH4Cl, extraction with EtOAc
  2. dry with materialdrying over MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-ef0297078d904383861d5ebed6d1655c
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09227971B2

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