Phosphorus oxychloride → 3-Methyl-1-benzothiophene-2-sulfonyl chloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

The 3-methylbenzothiophene-2-sulfonic acid (45 mg, 0.20 mmol) was mixed with POCl3 (2 mL, 20 mmol) and CH2Cl2 (2 mL) and heated at 70° C. for 6 h. The reaction mixture was diluted with CH2Cl2 before the reaction was quenched with ice and stirred at room temperature for 1 h. The organic phase was separated. Evaporation of the solvents afforded 57 mg the title compound (91%).

Herkunft & Nachweise