3-Aminobenzoic Acid → 3-{[(3-Methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid

HRID 589744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589744
[CH3:1][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][C:3]=1[S:11](Cl)(=[O:13])=[O:12].[NH2:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19]([OH:21])=[O:20]>>[CH3:1][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][C:3]=1[S:11]([NH:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19]([OH:21])=[O:20])(=[O:13])=[O:12]

Komponenten

3

Edukt 2

HCID 74193-Aminobenzoic AcidHCID 27368153-Methyl-1-benzothiophene-2-sulfonyl chloride2×

Produkt 1

HCID 569418883-{[(3-Methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acidAusbeute 26 %

Versuchsvorschrift

The product was prepared according to General Procedure 1, described in Example 1, with 3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 11) (25 mg, 0.10 mmol) and 3-aminobenzoic acid (28 mg, 0.20 mmol) using a modified reaction time (4 hours) and a modified reaction temperature (60° C.). The title compound was obtained in 26% yield (8.9 mg). MS (ESI+) calcd mass for C16H13NO4S2 347.028599, found 347.028659.

Aufarbeitung

  1. customThe product was prepared
  2. customa modified reaction time (4 hours)
  3. customa modified reaction temperature (60° C.)

Quellen und Nachweise

ORD-Eintrag
ord-6548f40e28314dffb41673a45bf6c5ad
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233946B2

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