Sodium Carbonate → Ticagrelor

HRID 589829Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589829
[CH3:1][CH2:2][CH2:3][S:4][C:5]1[N:6]=[C:7]([NH:25][C@H:26]2[C@H:28]([C:29]3[CH:30]=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([C@H:14]3[C@H:18]([OH:19])[C@H:17]([OH:20])[C@@H:16]([O:21][CH2:22][CH2:23][OH:24])[CH2:15]3)[C:9]=2[N:10]=1.C([O-])(=O)CC([O-])=O.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:1][CH2:2][CH2:3][S:4][C:5]1[N:6]=[C:7]([NH:25][C@H:26]2[C@H:28]([C:29]3[CH:30]=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([C@H:14]3[C@H:18]([OH:19])[C@H:17]([OH:20])[C@@H:16]([O:21][CH2:22][CH2:23][OH:24])[CH2:15]3)[C:9]=2[N:10]=1

Komponenten

4

Edukt 2

HCID 10340Sodium CarbonateHCID 131734470Ticagrelor malonate

Produkt 1

HCID 9871419Ticagrelor

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Ticagrelor malonate (0.5 g) and ethyl acetate (10 mL) were charged into round bottom flask. To the mixture 10% aqueous sodium carbonate solution (50 mL) was added and mixture was stirred for 15 minutes. The layers were separated and organic layer was subjected to distillation under vacuum to afford the title compound.

Aufarbeitung

  1. customThe layers were separated
  2. distillationorganic layer was subjected to distillation under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-31246c698edb43a1919f28f4968f9693
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233966B2

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