Methyl 2-methoxy-3-nitrobenzoate → Methyl 3-amino-2-methoxybenzoate

HRID 590117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 590117
[CH3:1][O:2][C:3]1[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]>CO.[Ni]>[NH2:13][C:12]1[C:3]([O:2][CH3:1])=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

Komponenten

4

Edukt 1

HCID 590805Methyl 2-methoxy-3-nitrobenzoate

Produkt 1

HCID 13338715Methyl 3-amino-2-methoxybenzoateAusbeute 96,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a solution of methyl 2-methoxy-3-nitrobenzoate (28.4 g, 134 mmol) in MeOH (150 mL) was added Raney Ni (3 g). The mixture was stirred under H2 atmosphere (50 psi/25° C.) for 3.5 h. The catalyst was filtered, and the filtrate was concentrated under the reduced pressure to dryness to give the crude product, which was purified by recrystallization in EtOAc to afford the title compound of Step C, methyl 3-amino-2-methoxybenzoate (23.5 g, 96.4% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 6.80-6.93 (m, 3H), 5.10-5.25 (br, 2H), 3.78 (s, 3H), 3.67 (s, 3H).

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated under the reduced pressure to dryness
  3. customto give the crude product, which
  4. customwas purified by recrystallization in EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-642d437a4efb429fb834df12b75e26b3
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233956B2

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