Paclitaxel → Baccatin Iii

HRID 590948

Reaktionsgleichung

Reaktionsgleichung von HRID 590948
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Komponenten

3

Edukt 2

HCID 36314PaclitaxelHCID 1844927-Epi-Taxol

Produkt 1

HCID 65366Baccatin Iii

Versuchsvorschrift

Degradation products were formed in the same proportions as in the experiments conducted under room temperature but in significantly lower quantities. Again, 7-epi-taxol was the main degradation product of paclitaxel. Its amounts formed during 32 h increased from about 3% at pH 7.0 to about 10% at pH 8.0 (see Table 11). Baccatin III and 10-deacethyltaxol were formed for about 5 to 6% at pH 8.0.

Aufarbeitung

  1. customDegradation products were formed in the same proportions as in the experiments
  2. customconducted under room temperature but in significantly lower quantities
  3. customIts amounts formed during 32 h
  4. temperatureincreased from about 3% at pH 7.0 to about 10% at pH 8.0 (see Table 11)

Quellen und Nachweise

ORD-Eintrag
ord-3853dc7c11d2490489bb61f620740aa9
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09238021B2

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