4-(Trifluoromethyl)aniline → 2-isopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

HRID 591244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 591244
Cl[C:2]1[N:7]2[N:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=[C:6]2[N:5]=[C:4]([CH3:14])[CH:3]=1.[F:15][C:16]([F:25])([F:24])[C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>C(O)C>[CH3:14][C:4]1[CH:3]=[C:2]([NH:21][C:20]2[CH:22]=[CH:23][C:17]([C:16]([F:15])([F:24])[F:25])=[CH:18][CH:19]=2)[N:7]2[N:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=[C:6]2[N:5]=1

Komponenten

4

Edukt 2

HCID 99644-(Trifluoromethyl)anilineHCID 533918637-Chloro-5-methyl-2-(1-methylethyl)[1,2,4]triazolo[1,5-a]pyrimidine

Produkt 1

HCID 513475412-isopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of Intermediate 18 (0.042 g, 0.199 mmol) in ethanol (5 mL), 4-(trifluoromethyl)aniline (ALDRICH, 0.025 mL, 0.199 mmol) was added and the mixture was stirred at room temperature overnight. Solvent was removed in vacuo and the crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures from 75:25 to 25:75%) to yield the title compound as a white solid.

Aufarbeitung

  1. additionwas added
  2. customSolvent was removed in vacuo
  3. customthe crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures from 75:25 to 25:75%)

Quellen und Nachweise

ORD-Eintrag
ord-8b9a3d0bb9f54527aca49771f97d39c2
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09238653B2

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