4-(Dimethylamino)-2-methoxybenzaldehyde → HCID 178493177, Verbindung

Beteiligte Stoffe

Reaktionsschritte

In a similar fashion to Compound LXXVI, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (40.0 mg, 0.118 mmol) and 4-dimethylamino-2-methoxy-benzaldehyde (23.3 mg, 0.130 mmol) were reacted to produce 25 mg (43%) of the title compound. mp: 218-220° C., 1H NMR (300 MHz, DMSO-d6): 13.00 (s, 1H), 8.24 (s, 1H), 8.00 (s, 1H), 7.96 (s, 1H), 7.73 (s, 1H), 6.99 (d, J=8 Hz, 2H), 6.43 (br s, 1H), 6.33 (br s, 1H), 5.16 (t, J=8 Hz, 1H), 3.94 (s, 3H), 2.87 (s, 1H), 2.73 (s, 1H), 2.59 (d, J=7 Hz, 1H), 2.23 (d, J=8 Hz, 1H), 1.90 (s, 1H), 1.37 (d, J=8 Hz, 1H). MS: 497, 499 (M+H), HPLC: 2.65 min (G method).

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