Trifluoroacetic acid → HCID 89726233, Verbindung

HRID 592088Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 592088
[CH:1]([C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[O:6][CH:7]1[CH2:12][CH2:11][N:10]([C:13](OC(C)(C)C)=[O:14])[CH2:9][CH2:8]1)=[O:2].C(O)([C:25]([F:28])([F:27])[F:26])=O>C(Cl)Cl>[F:26][C:25]([F:28])([F:27])[C:13]([N:10]1[CH2:11][CH2:12][CH:7]([O:6][C:5]2[CH:4]=[C:3]([CH:22]=[CH:21][CH:20]=2)[CH:1]=[O:2])[CH2:8][CH2:9]1)=[O:14]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 53439173tert-Butyl 4-(3-formylphenoxy)piperidine-1-carboxylate

Produkt 1

HCID 89726233HCID 89726233, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate (61) (5.55 mmol) was taken in DCM and cooled to 0° C. when TFA (5 ml) was added drop wise and then stirred at rt for 16 h when TLC confirmed completion of reaction. The reaction mixture was concentrated and used directly for the next step. White solid.

Aufarbeitung

  1. additionwas added drop wise
  2. customcompletion of reaction
  3. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3a4fccb6708048f1a3076f438139c3ae
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09238656B2

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