Sulfuric Acid → 2-Chloro-6-fluorobenzamide

HRID 59235

Reaktionsgleichung

Reaktionsgleichung von HRID 59235
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:12]>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]([NH2:5])=[O:12]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 695872-Chloro-6-fluorobenzonitrile

Produkt 1

HCID 985642-Chloro-6-fluorobenzamide

Versuchsvorschrift

A solution of 2-chloro-6-fluorobenzonitrile (8.0 g, 51.61 mmol) in conc. sulphuric acid (50 mL) was heated at 60-70° C. for 6-7 h. The reaction mass was quenched in water and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 5.5 g of desired product.

Aufarbeitung

  1. customThe reaction mass was quenched in water
  2. extractionextracted with DCM
  3. dry with materialThe organic layer was dried over anhydrous sodium sulphate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b073ea0b37854f5bad6f0a9176e3e856
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09439890B2

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