Toluene → HCID 58215694, Verbindung

HRID 593522

Reaktionsgleichung

Reaktionsgleichung von HRID 593522
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8][C:9]3[C:14]([CH:15]=2)=[CH:13][C:12]([C:16]#[N:17])=[CH:11][CH:10]=3)[CH:2]=1.C[Si]([N-][Si](C)(C)C)(C)C.[K+].C1(C)C=CC=CC=1.[C:35]([C:37]1[CH:38]=[C:39]([CH:43]=[CH:44][CH:45]=1)[C:40](Cl)=[O:41])#[N:36]>C1COCC1>[C:35]([C:37]1[CH:38]=[C:39]([CH:43]=[CH:44][CH:45]=1)[C:40]([N:8]1[C:9]2[C:14](=[CH:13][C:12]([C:16]#[N:17])=[CH:11][CH:10]=2)[CH:15]=[C:7]1[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:41])#[N:36]

Komponenten

6

Edukt 4

HCID 1140TolueneHCID 3084833-Cyanobenzoyl chlorideHCID 3251421Potassium bis(trimethylsilyl)amideHCID 445541352-pyridin-3-yl-1H-indole-5-carbonitrile

Produkt 1

HCID 58215694HCID 58215694, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-pyridin-3-yl-1H-indole-5-carbonitrile (Example 8, 210 mg, 0.96 mmol) in THF (20 mL) at room temperature is added 0.5 M KHMDS in toluene (4.10 mL, 2.05 mmol). After 30 min, 3-cyanobenzoyl chloride (510 mg, 3.08 mmol) is added. The mixture is stirred under N2 overnight. The reaction is quenched with aqueous ammonium chloride and the volatiles are removed in vacuo. The residue is redissolved in dichloromethane and poured into saturated aqueous sodium bicarbonate (100 mL). Extraction with dichloromethane, drying over sodium sulfate followed by concentration affords a residue which is purified on an XBridge RP18 using a 0.1% ammonium hydroxide in acetonitrile gradient. Further purification by silica gel flash chromatography (heptane-ethyl acetate, 3:2 to 2:3) affords 1-(3-cyano-benzoyl)-2-pyridin-3-yl-1H-indole-5-carbonitrile. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.20 (d, J=0.5 Hz, 1H), 7.22-7.26 (m, 1H), 7.55 (t, J=7.8 Hz, 1H), 7.73-7.79 (m, 2H), 7.84 (d, 1H), 7.92-7.98 (m, 2H), 8.11 (t, J=1.5 Hz, 1H), 8.29-8.33 (m, 1H), 8.39 (dd, J=4.8, 1.5 Hz, 1H), 8.60 (dd, J=2.3, 0.8 Hz, 1H). HRMS (ESI) m/z 349.1106 [(M+H)+ Calcd for C22H13N4O: 349.1089].

Aufarbeitung

  1. customThe reaction is quenched with aqueous ammonium chloride
  2. customthe volatiles are removed in vacuo
  3. dissolutionThe residue is redissolved in dichloromethane
  4. additionpoured into saturated aqueous sodium bicarbonate (100 mL)
  5. extractionExtraction with dichloromethane
  6. dry with materialdrying over sodium sulfate
  7. concentrationfollowed by concentration
  8. customaffords a residue which
  9. customis purified on an XBridge
  10. customFurther purification by silica gel flash chromatography (heptane-ethyl acetate, 3:2 to 2:3)

Quellen und Nachweise

ORD-Eintrag
ord-f042297fd86c4107a25e7381223dbdde
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242963B2

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